Plasma Blood Separator-An indispensable growth factor extraction equipment in the field of oral implantation！

In the field of oral implants, the new generation of plasma extraction concentrated growth factor (CGF) can significantly shorten the time of osteogenesis, improve the quality of osteogenesis, and promote the healing of bone tissue for local alveolar bone dysfunction or peripheral bone defects caused by various reasons.
CGF/PRF plasma blood separator is suitable for implantation, periodontal surgery, maxillofacial surgery, apical surgery, etc., such as maxillary sinus elevation, periimplantation inflammation, immediate implantation, site preservation, aesthetic area implantation, maxillary sinus membrane repair and other projects.

●Features

1. Use autologous blood. Centrifugation only through the patient's own blood is safe, reliable and easy to operate.
2. Promote tissue growth, shorten healing time, hardly cause any contamination, reduce swelling and pain!
3. The patient's own blood is centrifuged, and the rejection reaction is less than that of synthetic materials!
4. Hard tissue regeneration effect is good, high safety. Can be mixed with other filling materials!
5. Anti-infection Rich in immune cells, no added biochemical substances, no infection!

●The difference and application of PRP, A-PRF, I-PRF and CGF

Dental centrifuge currently has PRP, A-PRF, I-PRF, CGF these four special procedures, then PRP, A-PRF, I-PRF, CGF these four procedures in the end what is the difference? Where are their respective clinical applications? Today, let's have a brief discussion.

(PRP, PRF, CGF Development Process)

1.Platelet-rich plasma (PRP)

2.Platelet-rich fibrin (PRF)

Platelet-rich fibrin PRF stands for platelet rich fibrin. Unlike PRP, PRF does not require anticoagulants or thrombin. The blood was collected in 10 mL test tubes, without adding anticoagulants, and immediately centrifuged. During centrifugation, platelets passively strike the wall of the tube, so that cascade coagulation is activated. Lumps of fibrin and platelets mixed with plasma gather in the middle of the test tube.

At present, PRF technology is mainly divided into two types according to clinical use: APRF and IPRF, the former is gel-like form, the latter is liquid. Clinical difference and application:

A.IPRF is an injectable PRF extracted in liquid form by changing the extraction process. It contains a variety of growth factors, such as platelets, transforming growth factors, vascular endothelial growth factors and insulin-like growth factors, etc. Studies have shown that it has the function of promoting bone regeneration. When mixed with artificial bone meal, it presents a jelly-like mixture. Easy plasticity and maintenance of alveolar ridge.

B. APPRF is gel-like in clinical form, rich in platelets, white blood cells, especially various growth factors and cytokines, which can promote the movement, proliferation and differentiation of stem cells, promote new angiogenesis and collagen synthesis, and greatly accelerate bone growth when placed in dental implant sites. The vessels used are the same as those used by the CGF, with only differences in centrifugation procedures. It is generally used in clinical mixing with bone meal.

(APRF gel, low transmittance, fragile)

PRF technology has relatively low requirements on centrifuges, and doctors who know more about this technology can even extract PRF through some fixed-speed centrifuges. Because the clinical forms of APRF and CGF are similar, they are both gel-like, and are often confused by doctors.

The biggest difference is the pull depth of the gel, APRF is easily broken, not suitable for pressing film, generally used for mixing with bone meal filling and tooth extraction site preservation. Centrifuges that can prepare PRF are generally ordinary fixed-speed centrifuges. At the same time, some brand centrifuges do not distinguish between APRF and IPRF, and there is only one PRF option, which refers to PRF is actually APRF.

3.Concentrated growth factor (CGF)

CGF stands for Concentrate-Growth-Factors and, like PRF, does not require the addition of bovine thrombin or any anticoagulants.
However, compared to PRF, it is a different approach in the collection of blood samples and centrifugation procedures. CGF uses a variable speed of 2400-2700 rpm to isolate cells in venous blood, resulting in fibrin clots that are larger, denser, and rich in growth factors than conventional PRFS.
Basically, CGF is an upgraded version of PRF with enhanced fibrin clots and growth factors and cytokines. Because of its good stretchability, it is often used in clinical practice to make CGF membrane for covering wounds. At the same time, because it is a concentration of growth factors, it is often cut during planting surgery (because of its good tensile property, only surgical scissors can be cut) and used to mix bone meal for filling.

CGF technology has the highest requirements for centrifuges, which must be variable speed centrifuges, and the most essential difference with PRF is strength. The better the variable speed centrifuge program, the higher the CGF content prepared by the centrifuge (the percentage of CGF gel content in the total capacity of the blood collection tube) and the better the stretchability.

High levels mean that the CGF component is sufficient, and patients can obtain more CGF concentrated growth factor in a single blood draw. At the same time, high stretchability means that CGF has good quality, good toughness and better clinical wound coverage effect.

(CGF gel, lowest transmittance, non-breakable)

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